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KMID : 0382619930130010409
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Hanyang Journal of Medicine
1993 Volume.13 No. 1 p.409 ~ p.422
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Effects of Dantrolene and Verapamil on Neuromuscular Blockade by Pancuronium in Rabbits
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Abstract
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The effects of dantrolene end verapamil, calcium entry blocking agent, on the neuromuscular blockasde produced by pancuronium were studied in vivo on the indirectly stimulated tibialis anterior muscles of the rabbits anesthetized with urethane.
Control group of rabbits were given IV bolus of pancuronium 0.1mg/kg to produce complete twitch depression as measured by plantar flexion of the hindfoot in responses to common peroneal nerve stimulation and recovery index (the time for recovery
of
the
tension output T4 ratio 25% to 75%) was observed during spontaneous recovery. An experimental group of rabbits first recelved pancuronium 0.1mg/kg, producing complete depression of twitch amplitude, and then received the IV bolus of ddntrolene
2mg/kg
when T4 ratio 50% was recovered.
An additional one group of rabbits first received verapamil 0.1mg/kg followed by IV bolus of pancuronium 0.1mg/kg 5minutes later, to attain complete depression of twitch amplitude. Recovery idex and T1 : control % at T4 ratio 75% were also
observed
in
two experimental groups during spontaneous recovery. Dantrolene treated group produced prolongation of recovery index with initial dose of pancuronium from the control value of 457.8±225.3 seconds to 633.1±205.9 seconds.
Verapamil significantly decreased mean arterial and diastolic blood pressure. The T1 : control % of both dantrolene and verapamil groups were significantly decreased also. A presynaptic and postsynaptic effect of verapamil could not be discerned
in
this
study. The possible mechamism of neuromuscular actions, anesthetic implication of dantrolene and verapamil are discussed.
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KEYWORD
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